Авторы: Emery Jones, Stuart A. Walton
Перевод: Анна Феденева, ветеринарный врач-терапевт, эндокринолог.
Успешная окончательная терапия гиперкальциемии зависит от выявления и обратимости основного заболевания, при этом клинические признаки и прогноз зависят от причины и тяжести гиперкальциемии.
Список литературы:
- Coady M, Fletcher DJ, Goggs R. Severity of ionized hypercalcemia and hypocalcemia is associated with etiology in dogs and cats. Front Vet Sci. 2019;6:1-10. doi:10.3389/fvets.2019.00276
- Daniels E, Sakakeeny C. Hypercalcemia: pathophysiology, clinical signs, and emergent treatment. JAAHA. 2015;51(5):291-299. doi:10.5326/JAAHA-MS-6297
- Schneck PA, Chew DJ, Nagode LA, Rosol TJ. Disorders of calcium: hypercalcemia and hypocalcemia. In: DiBartola SP, ed. Fluid, Electrolyte, and Acid-Base Disorders in Small Animal Practice. 4th ed. Elsevier; 2012:120-194.
- De Witte F, Klag A, Chapman P. Adjusted calcium concentration as a predictor of ionized hypocalcemia in hypoalbuminemic dogs. J Vet Intern Med. 2021;35(5):2249-2255. doi:10.1111/jvim.16247
- Schenck PA, Chew DJ, Brooks CL. Fractionation of canine serum calcium, using a micropartition system. Am J Vet Res.1996;57(3):268-271.
- de Brito Galvão JF, Parker V, Schenck PA, Chew DJ. Update on feline ionized hypercalcemia. Vet Clin North Am Small Anim Pract. 2017;47(2):273-292. doi:10.1016/j.cvsm.2016.09.004
- Schenck PA, Chew DJ. Calcium: Total or ionized? Vet Clin North Am Small Anim Pract. 2008;38(3):497-502. doi:10.1016/j.cvsm.2008.01.010
- Groth EM, Chew DJ, Lulich JP, et al. Determination of a serum total calcium concentration threshold for accurate prediction of ionized hypercalcemia in dogs with and without hyperphosphatemia. J Vet Intern Med. 2020;34(1):74-82. doi:10.1111/jvim.15654
- van den Broek DHN, Geddes RF, Lötter NS, Chang YM, Elliott J, Jepson RE. Ionized hypercalcemia in cats with azotemic chronic kidney disease (2012-2018). J Vet Intern Med. 2022;36(4):1312-1321. doi:10.1111/jvim.16430
- Perović A, Bratičević MN. Time-dependent variation of ionized calcium in serum samples. Biochem Med (Zagreb). 2019;29(3):1-9. doi:10.11613/BM.2019.030708
- Schenck PA, Chew DJ. Prediction of serum ionized calcium concentration by serum total calcium measurement in cats. Can J Vet Res. 2010;74(3):209-213.
- Schenck PA, Chew DJ. Determination of calcium fractionation in dogs with chronic renal failure. Am J Vet Res. 2003;64(9):1181-1184. doi:10.2460/ajvr.2003.64.1181
- Schenck PA, Chew DJ. Prediction of serum ionized calcium concentration by use of serum total calcium concentration in dogs. Am J Vet Res. 2005;66(8):1330-1336. doi:10.2460/ajvr.2005.66.1330
- Hamroun A, Pekar JD, Lionet A, et al. Ionized calcium: analytical challenges and clinical relevance. J Lab Precis Med. 2020;5:22. doi:10.21037/jlpm-20-60
- Tung JK, Bowen RAR. Impact of underfilling heparinized collection tubes on ionized calcium measurements. Clin Chim Acta. 2020;503:233-235. doi:10.1016/j.cca.2019.11.017
- Robinson JL, Seiden-Long I, de Koning L. Identification and implementation of hemolysis interference thresholds in serum ionized calcium measurement. Clin Biochem. 2020;78:66-67. doi:10.1016/j.clinbiochem.2020.01.004
- Sachs C, Rabouine P, Chaneac M, Kindermans C, Dechaux M. In vitro evaluation of a heparinized blood sampler for ionized calcium measurement. Ann Clin Biochem. 1991;28(Pt 3):240-244. doi:10.1177/000456329102800307
- Lopez I, Felsenfeld AJ, Estepa JC, Rodriguez M, Aguilera-Tejero E. Effect of changes in ionized calcium concentration in arterial blood and metabolic acidosis on the arterial partial pressure of oxygen in dogs. Am J Vet Res. 2006;67(5):801-808. doi:10.2460/ajvr.67.5.801
- Schaer M. Therapeutic approach to electrolyte emergencies. Vet Clin North Am Small Anim Pract. 2008;38(3):513-533. doi:10.1016/j.cvsm.2008.01.012
- Calcium. eClinPath. Accessed November 13, 2023. Ссылка
- Messinger JS, Windham WR, Ward CR. Ionized hypercalcemia in dogs: a retrospective study of 109 cases (1998–2003). J Vet Intern Med. 2009;23(3):514-519. doi:10.1111/j.1939-1676.2009.0288.x
- Broughton SE, O’Neill DG, Syme HM, Geddes RF. Ionized hypercalcemia in 238 cats from a referral hospital population (2009-2019). J Vet Intern Med. 2023;37(1):80-91. doi:10.1111/jvim.16627
- Feldman EC. Hypercalcemia and primary hyperparathyroidism. In: Feldman EC, Nelson RW, Reusch CE, Scott-Moncrieff JCR, eds. Canine and Feline Endocrinology. 4th ed. Saunders; 2015:579-625.
- de Brito Galvão JF, Schenck PA, Chew DJ. A quick reference on hypercalcemia. Vet Clin North Am Small Anim Pract. 2017;47(2):241-248. doi:10.1016/j.cvsm.2016.10.016
- Kruger JM, Osbourne CA. Calcium disorders. In: Bartges J, Polzin D, eds. Nephrology and Urology of Small Animals. John Wiley & Sons, Inc.; 2011:642-656.
- Feldman EC, Hoar B, Pollard R, Nelson RW. Pretreatment clinical and laboratory findings in dogs with primary hyperparathyroidism: 210 cases (1987-2004). JAVMA. 2005;227(5):756-761. doi:10.2460/javma.2005.227.756
- Allen-Durrance AE. A quick reference on phosphorus. Vet Clin North Am Small Anim Pract. 2017;47(2):257-262. doi:10.1016/j.cvsm.2016.09.003
- Schropp DM, Kovacic J. Phosphorus and phosphate metabolism in veterinary patients. J Vet Emerg Crit Care. 2007;17(2):127-134. Ссылка
- Brudvig JM. VM 577–Hypercalcemia. Michigan State University Kaltura MediaSpace. April 8, 2021. Accessed November 13, 2023. Ссылка
- Liles SR, Linder KE, Cain B, Pease AP. Ultrasonography of histologically normal parathyroid glands and thyroid lobules in normocalcemic dogs. Vet Radiol Ultrasound. 2010;51(4):447-452. doi:10.1111/j.1740-8261.2010.01686.x
- Secrest S, Grimes J. Ultrasonographic size of the canine parathyroid gland may not correlate with histopathology. Vet Radiol Ultrasound. 2019;60(6):729-733. doi:10.1111/vru.12789
- Burkhardt SJ, Sumner JP, Mann S. Ambidirectional cohort study on the agreement of ultrasonography and surgery in the identification of parathyroid pathology, and predictors of postoperative hypocalcemia in 47 dogs undergoing parathyroidectomy due to primary hyperparathyroidism. Vet Surg. 2021;50(7):1379-1388. doi:10.1111/vsu.13707
- Armburst LJ, Biller DS, Bamford A, Chun R, Garrett LD, Sanderson MW. Comparison of three-view thoracic radiography and computed tomography for detection of pulmonary nodules in dogs with neoplasia. JAVMA. 2012;240(9):1088-1094. doi:10.2460/javma.240.9.1088
- Nemanic S, London CA, Wisner ER. Comparison of thoracic radiographs and single breath-hold helical CT for detection of pulmonary nodules in dogs with metastatic neoplasia. J Vet Intern Med. 2006;20(3):508-515. doi:10.1892/0891-6640(2006)20[508:cotras]2.0.co;2
- Moore EL, Vernau W, Rebhun RB, Skorupski KA, Burton JH. Patient characteristics, prognostic factors and outcome of dogs with high-grade primary mediastinal lymphoma. Vet Comp Oncol. 2018;16(1):E45-E51. doi:10.1111/vco.12331
- Fields EL, Robertson ID, Osborne JA, Brown Jr JC. Comparison of abdominal computed tomography and abdominal ultrasound in sedated dogs. Vet Radiol Ultrasound. 2012;53(5):513-517. doi:10.1111/j.1740-8261.2012.01949.x
- Groman RP. Acute management of calcium disorders. Top Companion Anim Med. 2012;27(4):167-171. doi:10.1053/j.tcam.2012.11.002
- Brewer DJ, Macfarlane M, O’Connell E, Bacon NJ. Toxicity of zoledronic acid after intravenous administration: a retrospective study of 95 dogs. J Vet Intern Med. 2022;36(1):253-258. doi:10.1111/jvim.16335
- Hostutler RA, Chew DJ, Jaeger JQ, Klein S, Henderson D, DiBartola SP. Uses and effectiveness of pamidronate disodium for treatment of dogs and cats with hypercalcemia. J Vet Intern Med. 2005;19(1):29-33. doi:10.1892/0891-6640(2005)19<29:uaeopd>2.0.co;2
- Kurtz M, Desquilbet L, Maire J, et al. Alendronate treatment in cats with persistent ionized hypercalcemia: a retrospective cohort study of 20 cases. J Vet Intern Med. 2022;36(6):1921-1930. doi:10.1111/jvim.16508
- Lopes MG, Tosi G, McNaught KA, Morris JS. Retrospective assessment of tolerability and efficacy of zoledronate in the palliative treatment of cancer-bearing dogs. Aust Vet J. 2023;101(1-2):58-64. doi:10.1111/avj.13218
- Schenk A, Lux C, Lane J, Martin O. Evaluation of zoledronate as treatment for hypercalcemia in four dogs. JAAHA. 2018;54(6):e54604. doi:10.5326/JAAHA-MS-6681
- Ward H, Schenck P, Lupo M, Dano J, Chew D. Abstract EN17. Efficacy and tolerability of generic cinacalcet in dogs with primary hyperparathyroidism. 2022 ACVIM Forum Research Abstract Program. J Vet Intern Med. 2022;36:2282-2454. doi:10.1111/jvim.16541