Заболевания кожи

Автор: Летуновская А. В., ветеринарный врач-онколог, член Европейского общества ветеринарных онкологов (ESVONC). Ветеринарная клиника неврологии, травматологии и интенсивной терапии, г. Санкт-Петербург.

Определения, анатомия

Кожа, на взгляд онколога, – орган, состоящий преимущественно из двух слоев: эпидермиса (многослойный плоский эпителий) и дермы, представляющей собой плотную соединительную ткань с множеством сосудов. 
Кроме того, интерес представляют отдельные клетки (меланоциты, гистиоциты и дермальные тучные клетки), а также так называемые придатки кожи (сальные и потовые железы, волосяные фолликулы). Любые из этих тканей/клеток могут являться сайтом/локализацией для развития доброкачественных или злокачественных опухолей 65.

Список литературы:
  1. Aitken, M.L. and A.K. Patnaik. Comparison of needle-core (Trucut) biopsy and surgical biopsy for the diagnosis of cutaneous and subcutaneous masses: a prospective study of 51 cases (November 1997–August 1998). J Am Anim Hosp Assoc. 2000, 36(2):153–157.
  2. Alberdein, D., J.S. Munday, C.B. Dyer, et al. Comparison of the histology and immunohistochemistry of vaccination-site and non-vaccination-site sarcomas from cats in New Zealand. NZ Vet J.2007, 55(5):203–207.
  3. Baer KE, Helton K. Multicentric squamous cell carcinoma in situ resembling Bowen’s disease in cats, Vet Pathol. 1993, 30:535–543.
  4. Baker-Gabb, M., G.B. Hunt, and M.P. France. 2003. Soft tissue sarcomas and mast cell tumours in dogs: Clinical behaviour and response to surgery. Aust Vet J. 2003, 81(12):732–738.
  5. Bostock D. The prognosis following surgical removal of mastocytomas in dogs. Journal of Small Animal Practice. 1973, 14:27–40.
  6. Bostock DE: Neoplasia of the skin and mammary glands in dogs and cats. In Kirk RW, editor: Current veterinary therapy small animal practice, Philadelphia, 1977, WB Saunders. 
  7. Braathen LR, Szeimies RM, Basset-Seguin N, et al. Guidelines on the use of photodynamic therapy for nonmelanoma skin cancer: An international consensus. International Society for Photodynamic Therapy in Dermatology, 2005, J Am Acad Dermatol. 2007, 56:125–143.
  8. Buchholz J, Wergin M, Walt H, et al. Photodynamic therapy of feline cutaneous squamous cell carcinoma using a newly developed liposomal photosensitizer: preliminary results concerning drug safety and efficacy, J Vet Intern Med. 2007, 21:770–775.
  9. Buhles WC Jr, Theilen GH. Preliminary evaluation of bleomycin in feline and canine squamous cell carcinoma, Am J Vet Res.1973, 34:289–291.
  10. Callan MB, Preziosi D, Mauldin E. Multiple papillomavirusassociated epidermal hamartomas and squamous cell carcinomas in situ in a dog following chronic treatment with prednisone and cyclosporine, Vet Dermatol. 2005, 16:338–345.
  11. Carpenter JL, Andrews LK, Holzworth J: Tumors and tumor-like lesions. In Holzworth J, editor: Diseases of the cat: medicine and surgery, Philadelphia, 1987, WB Saunders.
  12. Cockerell GL, Slauson DO. Patterns of lymphoid infiltrate in the canine cutaneous histiocytoma, J Comp Pathol. 1979, 89:193–203.
  13. David J Argyle at all. Decision making in small animal oncology / David J. Argyle, Malcolm J. Brearley, Michelle M. Turek.—1st ed. p.; cm.
  14. Davidson, E.B., C.R. Gregory, and P.H. Kass. Surgical excision of soft tissue fibrosarcomas in cats. Vet Surg. 1997,  26(4):265–269.
  15. Davis, K.M., E.M. Hardie, B.D. Lascelles, et al. Feline fibrosarcoma: Perioperative management. Compend Contin Educ Vet. 2007, 29(12):712–714.
  16. Day DG, Couto CG, Weisbrode SE, et al. Basal cell carcinoma in two cats, J Am Anim Hosp Assoc. 1994, 30:265–269.
  17. Dernell, W.S., S.J. Withrow, C.A. Kuntz, et al. Principles of treatment for soft tissue sarcoma. Clin Tech Small Anim Pract. 1998, 13(1):59–64.
  18. Dillon, C.J., G.N. Mauldin, and K.E. Baer. Outcome following surgical removal of nonvisceral soft tissue sarcomas in cats: 42 cases (1992–2000). J Am Vet Med Assoc. 2005, 227(12):1955–1957.
  19. Diters RW, Walsh KM: Feline basal cell tumors: A review of 124 cases, Vet Pathol. 1984,21:51–56.
  20. Dobson J.M., Lascelles D. BSAVA Manual of canine and feline oncology. 2 ed. Wiley, 2003.
  21. Dobson, J.M., S. Samuel, H. Milstein, et al. Canine neoplasia in the UK: Estimates of incidence rates from a population of insured dogs. J Small Anim Pract. 2002, 43(6):240–246.
  22. Dorn CR, Taylor DO, Schneider R. Sunlight exposure and risk of developing cutaneous and oral squamous cell carcinomas in white cats, J Natl Cancer Inst .1971,46:1073–1078. 
  23. Ehrhart, N. 2005. Soft-tissue sarcomas in dogs: A review. J Am Anim Hosp Assoc 41(4):241–246.
  24. Enneking, W.F. and G.E. Maale. The effect of inadvertent tumor contamination of wounds during the surgical resection of musculoskeletal neoplasms. Cancer.1988, 62(7):1251–1256.
  25. Ettinger, S.N. Principles of treatment for soft-tissue sarcomas in the dog. Clin Tech Small Anim Pract. 2003, 18(2):118–122.
  26. Ettinger, S.N., T.J. Scase, K.T. Oberthaler, et al. Association of argyrophilic nucleolar organizing regions, Ki-67, and proliferating cell nuclear antigen scores with histologic grade and survival in dogs with soft tissue sarcomas: 60 cases (1996–2002). J Am Vet Med Assoc. 2006, 228(7):1053–1062.
  27. Fidel JL, Egger E, Blattmann H, et al. Proton irradiation of feline nasal planum squamous cell carcinomas using an accelerated protocol, Vet Radiol Ultrasound. 2001,42:569–575.
  28. Frimberger A., Moore A., LaRue S. et al. Radiotherapy of incompletely resected moderately differentiated mast cell tumours in the dog: 37 cases (1989–1993). Journal of the American Animal Hospital Association. 1997, 33:320–323.
  29. Fulcher R.P., Ludwig L.L., Bergman P.J., Newman S.J., Simpson A.M., Patnaik A.K. Evaluation of a two-centimeter lateral surgical margin for excision of grade I and grade II cutaneous mast cell tumors in dogs. Journal of the American Veterinary Medical Association. 2006, 15; 228:210–215.
  30. Gaitero, L., S. Anor, D. Fondevila, et al. Canine cutaneous spindle cell tumours with features of peripheral nerve sheath tumours: A histopathological and immunohistochemical study. J Comp Pathol. 2008, 139(1):16–23.
  31. Ghisleni, G., P. Roccabianca, R. Ceruti, et al. Correlation between fine-needle aspiration cytology and histopathology in the evaluation of cutaneous and subcutaneous masses from dogs and cats. Vet Clin Pathol. 2006, 35(1):24–30.
  32. Gill VL, Bergman PJ, Baer KE, et al: Use of imiquimod 5% cream (Aldara) in cats with multicentric squamous cell carcinoma in situ: 12 cases (2002-2005), Vet Comp Oncol. 2008, 6:55–64.
  33. Gilson, S.D. and E.A. Stone. Surgically induced tumor seeding in eight dogs and two cats. J Am Vet Med Assoc. 1990, 196(11):1811–15.
  34. Goldschmidt MH, Hendrick MJ: Tumors of the skin and soft tissues, In Meuten DJ, editor: Tumors in domestic animals, ed 4, Ames, Iowa, 2002, Iowa State Press.
  35. Goldschmidt MH, Shofer FS: Squamous cell carcinoma. In Skin tumors of the dog and cat. Oxford, 1998, Reed Educational and Professional Publishing Ltd.
  36. Goodfellow M, Hayes A, Murphy S, et al. A retrospective study of (90)Strontium plesiotherapy for feline squamous cell carcinoma of the nasal planum, J Feline Med Surg. 2006, 8:169–176.
  37. Gross TL, Brimacomb BH. Multifocal intraepidermal carcinoma in a dog histologically resembling Bowen’s disease, Am J Dermatopathol, 8:509–515, 1986.
  38. Gross TL, Ihrke PJ, Walder EJ, et al. Epidermal tumors. In Gross TL, Ihrke PJ, Walder EJ, et al, editors: Skin diseases in the dog and cat: clinical and histopathologic diagnosis, Ames, Iowa, 2005, Blackwell Science Ltd.
  39. Gross TL, Ihrke PJ, Walder EJ, et al. Sweat gland tumors. In Gross TL, Ihrke PJ, Walder EJ, et al, editors: Skin diseases of the dog and cat: clinical and histopathologic diagnosis, ed 2, Ames, Iowa, 2005, Blackwell Science Ltd.
  40. Hammer AS, Couto CG, Ayl RD, et al. Treatment of tumor-bearing dogs with actinomycin D, J Vet Intern Med. 1994, 8:236–239.
  41. Hammond GM, Gordon IK, Theon AP, et al. Evaluation of strontium Sr 90 for the treatment of superficial squamous cell carcinoma of the nasal planum in cats: 49 cases (1990-2006), J Am Vet Med Assoc 231:736–741, 2007.
  42. Hargis AM, Thomassen RW, Phemister RD: Chronic dermatosis and cutaneous squamous cell carcinoma in the beagle dog, Vet Pathol. 1977, 14:218–228. 
  43. Hausen H. Human papillomavirus & cervical cancer, Indian J Med Res. 2009,130:209. 
  44. Hayes A., Adams V., Smith K., Maglennon G., Murphy S. Vinblastine and prednisolone chemotherapy for surgically excised grade III canine cutaneous mast cell tumours. Veterinary and Comparative Oncology. In press.
  45. Jaffe M., Hosgood G., Kerwin S. et al. Deionised water as an adjunct to surgery for the treatment of canine cutaneous mast cell tumors. Journal of Small Animal Practice. 2000, 41:1–7.
  46. Kaldrymidou H, Leontides L, Koutinas AF, et al. Prevalence, distribution and factors associated with the presence and the potential for malignancy of cutaneous neoplasms in 174 dogs admitted to a clinic in northern Greece, J Vet Med A Physiol Pathol Clin Med, 49:87–91, 2002.
  47. Klausner JS, Bell FW, Hayden DW, et al. Hypercalcemia in two cats with squamous cell carcinomas, J Am Vet Med Assoc.1990, 196:103–105.
  48. Knowles DP, Hargis AM: Solar elastosis associated with neoplasia in two dalmations, Vet Pathol.1986, 23:512–514. 
  49. Kuntz, C.A., W.S. Dernell, B.E. Powers, et al. Prognostic factors for surgical treatment of soft-tissue sarcomas in dogs: 75 cases (1986–1996). J Am Vet Med Assoc. 1997, 211(9):1147–1151.
  50. LaDue T., Price G., Dodge R. et al. Radiation therapy for incompletely resected canine mast cell tumours. Veterinary Radiology and Ultrasound. 1998, 39:57–62.
  51. Lana SE, Ogilvie GK, Withrow SJ, et al. Feline cutaneous squamous cell carcinoma of the nasal planum and the pinnae: 61 cases, J Am Anim Hosp Assoc, 33:329–332, 1997.
  52. Langenbach, A., P.M. Mcmanus, M.J. Hendrick, et al. Sensitivity and specificity of methods of assessing the regional lymph nodes for evidence of metastasis in dogs and cats with solid tumors. J AmVet Med Assoc. 2001, 218(9):1424–1428.
  53. Lascelles BD, Henderson RA, Seguin B, et al. Bilateral rostral maxillectomy and nasal planectomy for large rostral maxillofacial neoplasms in six dogs and one cat, J Am Anim Hosp Assoc, 40:137–146, 2004.
  54. Lascelles BD, Parry AT, Stidworthy MF, et al. Squamous cell carcinoma of the nasal planum in 17 dogs, Vet Rec, 147:473–476, 2000.
  55. Liptak, J.M. 2007. Soft tissue sarcomas. In Withrow and MacEwen’s Small Animal Clinical Oncology, pp. 425–454. S.J. Withrow and E.G. MacEwen, editors. WB Saunders: St. Louis.
  56. Madewell BR, Conroy JD, Hodgkins EM. Sunlight-skin cancer association in the dog: a report of three cases, J Cutan Pathol. 1981, 8:434–443. 
  57. McColl Williamson, M. and D.J. Middleton. Cutaneous soft tissue tumours in dogs: Classification, differentiation, and histogenesis. Vet Dermatol. 1998, 9(1):43–48.
  58. McEntee, M.C. and V.F, Samii. The utility of contrast enhanced computed tomography in feline vaccine associated sarcomas: 35 cases [abstract]. Vet Radiol Ultrasound.2000, 41:575.
  59. McManus P. Frequency and severity of mastocytemia in dogs with and without mast cell tumors: 120 cases (1995–1997). Journal of the American Veterinary Medical Association. 1999215:355–357.
  60. McSporran, K. Histologic grade predicts recurrence for marginally excised canine subcutaneous soft tissue sarcomas. Vet Pathol. 2009, 46(5):928–933.
  61. Donald J. Meuten (editor). Tumors in domestic animals, 5th Edition/ John Wiley & Sons Inc., 2017.
  62. Miller D. The occurrence of mast cell tumours in young sharpeis. Journal of Veterinary Diagnostic Investigation. 1995, 7:360–363.
  63. Miller, M.A., S.L. Nelson, J.R. Turk, et al. Cutaneous neoplasia in 340 cats. Vet Pathol. 1991, 28(5):389–395.
  64. Misdorp W. Mast cells and canine mast cell tumours // A review. Vet. Q. 2004. Dec.
  65. Moloney FJ, Comber H, O’Lorcain P, et al. A population-based study of skin cancer incidence and prevalence in renal transplant recipients, Br J Dermatol, 154:498–504, 2006. 
  66. Morris, Joanna. Small animal oncology/Joanna Morris and Jane Dobson., Argyle, David J. Decision making in small animal oncology / David J. Argyle, Malcolm J. Brearley, Michelle M. Turek.—1st ed. p.; cm.
  67. Mukaratirwa, S., J. Chipunza, S. Chitanga, et al. Canine cutaneous neoplasms: Prevalence and influence of age, sex and site on the presence and potential malignancy of cutaneous neoplasms in dogs from Zimbabwe. J S Afr Vet Assoc. 2005, 76(2):59–62.
  68. Munday JS, Gibson I, French AF. Papillomaviral DNA and increased p16CDKN2A protein are frequently present within feline cutaneous squamous cell carcinomas in ultraviolet-protected skin, Vet Dermatol, 22:360–366, 2011.
  69. Munday JS, Kiupel M. Papillomavirus-associated cutaneous neoplasia in mammals, Vet Pathol, 47:254–264, 2010.
  70. Murphy S., Sparkes A.H., Smith K.C., Blunden A.S., Brearley M.J. Relationships between the histological grade of cutaneous mast cell tumours in dogs, their survival and the effi cacy of surgical resection. Veterinary Record. 2004, 12; 154:743–746.
  71. Narayanan DL, Saladi RN, Fox JL: Ultraviolet radiation and skin cancer, Int J Dermatol, 49:978–986, 2010.
  72. Nikula KJ, Benjamin SA, Angleton GM, et al. Ultraviolet radiation, solar dermatosis, and cutaneous neoplasia in beagle dogs, Radiat Res, 129:11–18, 1992. 
  73. Northrup N.C., Howerth E.W., Harmon B.G., Brown C.A., Carmicheal K.P., Garcia A.P., Latimer K.S., Munday J.S., Rakich P.M., Richey L.J., Stedman N.L., Gieger T.L. Variation among pathologists in the histologic grading of canine cutaneous mast cell tumors with uniform use of a single grading reference. Journal of Veterinary Diagnostic Investigation. 2005, 7(6):561–564.
  74. Ogilvie GK, Moore AS, Obradovich JE, et al. Toxicoses and efficacy associated with administration of mitoxantrone to cats with malignant tumors, J Am Vet Med Assoc, 202:1839–1844, 1993.
  75. Ogilvie GK, Obradovich JE, Elmslie RE, et al. Efficacy of mitoxantrone against various neoplasms in dogs, J Am Vet Med Assoc, 198:1618–1621, 1991.
  76. Owen LN: TNM classification of tumors in domestic animals, Geneva, 1980, World Health Organization.
  77. Patnaik, A.K., Ehler W., MacEwan G. Canine cutaneous mast cell tumor: Morphologic grading and survival time in 83 dogs. Veterinary Pathology. 1984, 21:469–474.
  78. Peaston AE, Leach MW, Higgins RJ. Photodynamic therapy for nasal and aural squamous cell carcinoma in cats, J Am Vet Med Assoc, 202:1261–1265, 1993.
  79. Rassnick K.M., Moore A.S., Williams L.E., London C.A., Kintzer P.P., Engler S.J., Cotter S.M. Treatment of canine mast cell tumors with CCNU (lomustine). Journal of Veterinary Internal Medicine. 1999, 13(6):601–606.
  80. Rothwell TL, Howlett CR, Middleton DJ, et al. Skin neoplasms of dogs in Sydney, Aust Vet J. 64:161–164, 1987.
  81. Savary KC, Price GS, Vaden SL. Hypercalcemia in cats: A retrospective study of 71 cases (1991-1997), J Vet Intern Med, 14:184–189, 2000.
  82. Schwegler K, Walter JH, Rudolph R. Epithelial neoplasms of the skin, the cutaneous mucosa and the transitional epithelium in dogs: an immunolocalization study for papillomavirus antigen, Zentral Veterinarmed A. 1997, 44:115–123.
  83. Seguin, B., Leibman, N.F., Bregazzi, V.S. et al. Clinical outcome of dogs with grade-II mast cell tumors treated with surgery alone: 55 cases (1996–1999). Journal of the American Veterinary Medical Association. 2001, 218:1120–1123. 
  84. Shelly, S.M. Cutaneous lesions. Vet Clin North Am Small Anim Pract. 2003, 33(1):1–46.
  85. Simon T. Kudnig, Bernard Seguin Veterinary surgical oncology / [edited by] Simon T. Kudnig, Bernard Sйguin ; illustrations by Dave Carlson.
  86. Simon, D., D.M. Ruslander, K.M. Rassnick, et al. Orthovoltage radiation and weekly low dose of doxorubicin for the treatment of incompletely excised soft-tissue sarcomas in 39 dogs. Vet Rec. 2007, 160(10):321–326.
  87. Simpson A.M., Ludwig L.L., Newman S.J., Bergman P.J., Hottinger H.A., Patnaik A.K. Evaluation of surgical margins required for complete excision of cutaneous mast cell tumors in dogs. Journal of the American Veterinary Medical Association. 2004, 15; 224(2):236–240.
  88. Stockfleth E, Nindl I, Sterry W, et al. Human papillomaviruses in transplant-associated skin cancers, Dermatol Surg. 2004,30:604–609.
  89. Stockfleth E, Ulrich C, Meyer T, et al. Skin diseases following organ transplantation–risk factors and new therapeutic approaches, Transplant Proc. 2001,33:1848–1853. 
  90. Stockhaus C, Teske E, Rudolph R, et al. Assessment of cytological criteria for diagnosing basal cell tumours in the dog and cat, J Small Anim Pract, 42:582–586, 2001.
  91. Thamm D.H., Mauldin E.A., Vail D.M. Prednisolone and vinblastine chemotherapy for canine mast cell tumor—41 cases (1992–1997). Journal of Veterinary Internal Medicine. 1999, 13(5):491–497.
  92. Thamm D.H., Turek M.M., Vail D.M. 2006. Outcome and prognostic factors following adjuvant prednisolone/vinblastine chemotherapy for high-risk canine mast cell tumour: 61 cases. Journal of Veterinary Medical Science 68(6):581–587.
  93. Theilen, G.H. and B.R. Madewell. 1979. Veterinary Cancer Medicine. Lea & Febiger: Philadelphia.
  94. Theon AP, Madewell BR, Shearn VI, et al. Prognostic factors associated with radiotherapy of squamous cell carcinoma of the nasal plane in cats, J Am Vet Med Assoc 206:991–996, 1995.
  95. Theon AP, VanVechten MK, Madewell BR. Intratumoral administration of carboplatin for treatment of squamous cell carcinomas of the nasal plane in cats, Am J Vet Res. 1996, 57:205–210,..
  96. Thrall DE, Adams WM. Radiotherapy of squamous cell carcinomas of the canine nasal plane, Vet Radiol, 23:193–195, 1982.
  97. Turrell J.M., Kitchell B., Miller L.M., et al. Prognostic factors for radiation treatment of mast cell tumor in 85 dogs. Journal of the American Veterinary Medical Association. 1988,193:936–940.
  98. Weisse C., Shofer F.S., Sorenmo K. Recurrence rates and sites for grade II canine cutaneous mast cell tumors following complete surgical excision. Journal of the American Animal Hospital Association. 2002, 38:71–73.
  99. Withrow and MacEwan’s Small Animal Clinical Oncology, 4th edition. 2007. W.B. Saunders, Encinitas, CA, pp. 402–416.
  100. Withrow, S.J., Vail, D.M. 2007. Small Animal Clinical Oncology, 4th edition. W.B. Saunders, Encinitas, California.