Действительно ли Апоквел (оклацитиниб) эффективен для лечения кошек?
Дерматология

Действительно ли Апоквел (оклацитиниб) эффективен для лечения кошек?

Авторы: Герасимова Е. О., Зиновьева А. Ю. Ветеринарная клиника доктора Сотникова, г. Санкт-Петербург.

Зуд – неприятное ощущение, которое может заставлять животное тереть, жевать или расчесывать кожу или слизистые. Он возникает в коже в ответ на ее воспаление или повреждение. Зуд сопровождает многие заболевания кожи, особенно вызванные паразитами и реакциями гиперчувствительности, и является одной из самых частых причин обращения владельцев в клинику. Наибольшее значение имеет контроль зуда у кошек при реакциях гиперчувствительности – аллергиях.

Список литературы:
  1. Hobi S., Linek M., Marignac G., Olivry T., Beco L. et al. Clinical characteristics and causes of pruritus in cats: a multicentre study on feline hypersensitivity-associated dermatoses. Vet Dermatol. 2011 Oct; 22(5):406-13. 
  2. Diesel A. Cutaneous hypersensitivity dermatoses in the feline patient: a review of allergic skin disease in cats. Vet Sci. 2017 May 9; 4(2). 
  3. Donald C. Plumb, Pharm. D. Glucocorticoid agents, general information. Plumb’s Veterinary Drug Handbook, 7th Edition, 2011.
  4. Lowe A.D., Campbell K.L., Graves T. Glucocorticoids in the cat. Vet Dermatol. 2008 Dec; 19(6):340-7. 
  5. Robson D. Review of the properties and mechanisms of action of cyclosporine with an emphasis on dermatological therapy in dogs, cats and people. Vet Rec. 2003 Jun 21;152(25):768-72. 
  6. Heinrich N.A., McKeever P.J., Eisenschenk M.C. Adverse events in 50 cats with allergic dermatitis receiving ciclosporin. Vet Dermatol. 2011 Dec; 22(6):511-20.
  7. Last R.D., Suzuki Y., Manning T., Lindsay D., Galipeau L., Whitbread T.J. A case of fatal systemic toxoplasmosis in a cat being treated with cyclosporin A for feline atopy. Vet Dermatol. 2004 Jun;15(3):194-8.
  8. Garibyan L., Rheingold C.G., Lerner E.A. Understanding the pathophysiology of itch. Dermatol Ther. 2013 Mar-Apr; 26(2):84-91. 
  9. Wildermuth K., Zabel S., Rosychuk R.A.The efficacy of cetirizine hydrochloride on the pruritus of cats with atopic dermatitis: a randomized, double-blind, placebo-controlled, crossover study. Vet Dermatol. 2013 Dec; 24(6):576-81.
  10. Rosanna Marsella. Hypersensitivity Disorders. Muller&Kirk’s Small Animal Dermatology, 7th edition, 2013.
  11. Donald C. Plumb, Pharm.D. Fatty  acids, essential/omega fish oil/vegetable oil. Plumb’s Veterinary Drug Handbook, 7th Edition, 2011.
  12. Marsella R., Cornegliani L., Ozmen I., Bohannon M., Ahrens K., Santoro D. Randomized, double-blinded, placebo-controlled pilot study on the effects of topical blackcurrant emulsion enriched in essential fatty acids, ceramides and 18-beta glycyrrhetinic acid on clinical signs and skin barrier function in dogs with atopic dermatitis. Vet Dermatol. 2017 Dec; 28(6):577-e140. 
  13. Scott D.W1, Miller W.H. Jr., Decker G.A., Wellington J.R. Comparison of the clinical efficacy of two commercial fatty acid supplements (EfaVet and DVM Derm Caps), evening primrose oil, and cold water marine fish oil in the management of allergic pruritus in dogs: a double-blinded study. Cornell Vet. 1992 Jul;82(3):319-29.
  14. Dawn B. Logas, Gail A. Kunkle. Double‐blinded Study Examining the Effects of Evening Primrose Oil on Feline Pruritic Dermatitis. Vet Dermatol. 2008 Mar; 4(4):181-184.
  15. Park H.J., Park J.S., Hayek M.G., Reinhart G.A., Chew B.P. Dietary fish oil and flaxseed oil suppress inflammation and immunity in cats. Vet Immunol Immunopathol. 2011 Jun 15;141(3-4):301-6.
  16. Scott D.W., Miller W.H. The combination of antihistamine (chlorpheniramine) and an omega-3/omega-6 fatty acid-containing product for the management of pruritic cats: results of an open clinical trial. N Z Vet J. 1995 Feb;43(1):29-31.
  17. Gonzales A.J., Bowman J.W., Fici G.J., Zhang M., Mann D.V., Mitton-Fry M Oclacitinib (APOQUEL(®)) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. J Vet Pharmacol Ther. 2014 Aug; 37(4):317-24.
  18. Santoro G.Therapies in Canine Atopic Dermatitis: An Update. Vet Clin North Am Small Anim Pract. 2019 Jan; 49(1):9-26. 
  19. Christian Ortalda, Chiara Noli, Silvia Colombo and Stefano Borio. Oclacitinib in feline nonflea-, nonfood-induced hypersensitivity dermatitis: results of a small prospective pilot study of client-owned cats. Vet Dermatol 2015; 26: 235–e52.
  20. Noli C, Matricoti I, Schievano C. A double-blinded, randomized, methylprednisolone-controlled study on the efficacy of oclacitinib in the management of pruritus in cats with nonflea nonfood-induced hypersensitivity dermatitis.Vet Dermatol. 2019 Apr;30(2):110-e30.
  21. A.K. Burrows, M.K. Siak. Immune‐modulating drugs in cats: new perspectives and old favourites. Advances in Veterinary Dermatology, Volume 8 (Materials of 8th World Congress of veterinary dermatology, 2016).
  22. Little P.R., King V.L., Davis K.R., Cosgrove S.B., Stegemann M.R. A blinded, randomized clinical trial comparing the efficacy and safety of oclacitinib and ciclosporin for the control of atopic dermatitis in client-owned dogs. Vet Dermatol. 2015 Feb;26(1):23-30, e7-8.
  23. Cosgrove S.B., Cleaver D.M., King V.L., Gilmer A.R., Daniels A.E., Wren J.A., Stegemann M.R. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. Vet Dermatol. 2015 Jun;26(3):171-9, e35.
  24. Andrew C. Simpson, Jennifer R. Schissler, Rod A.W. Rosychuk and A Russell Moore.
  25. The frequency of urinary tract infection and subclinical bacteriuria in dogs with allergic dermatitis treated with oclacitinib: a prospective study. Vet Dermatol 2017; 28: 485–e113.
  26. Peterson A.L., Torres S.M., Rendahl A., Koch S.N. Frequency of urinary tract infection in dogs with inflammatory skin disorders treated with ciclosporin alone or in combination with glucocorticoid therapy: a retrospective study. Vet Dermatol. 2012 Jun; 23(3):201-e43. 
  27. Torres S.M., Diaz S.F., Nogueira S.A., Jessen C., Polzin D.J., Gilbert S.M., Horne K.L. Frequency of urinary tract infection among dogs with pruritic disorders receiving long-term glucocorticoid treatment. J Am Vet Med Assoc. 2005 Jul 15; 227(2):239-43.